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. 2022 Jan 26;11:822745. doi: 10.3389/fonc.2021.822745

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Copyright © 2022 Yang, Chen, Guo, Dai, Tang, Zhao, Wu, Li, Du, Shen, Yi, Xiao and Wen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network of competitive endogenous RNAs. (A) mRNAs, lncRNAs, and circRNAs all contain microRNA (miRNA) response elements (MREs) that can bind to miRNAs and regulate the expression of RNA targets at the post-transcriptional level. (B) LINC01133 exerts oncogenic effect by acting as a sponge for miR-106-3p, which regulates the expression of APC and inactivates the Wnt/β-catenin signaling pathway. circCYFIP2 exerts oncogenic effect by acting as a sponge for miR-1205, which regulates the expression of E2F1. miRNA-204 inhibits the transcription of CKS1B, CXCL1 and GPRC5A mRNAs by binding to AGO2 to form the RISC complex, which ultimately inhibits the proliferation of GC.