Table 2.
lncRNAs regulate histone modification in GC.
| lncRNA | Expression | Mechanism | Target | Function | Reference |
|---|---|---|---|---|---|
| lncRNA SNHG5 | Downregulation | Histone acetylation | MTA2, NuRD | Tumor suppressor | (102) |
| lncRNA MALAT1 | Upregulation | EGFL7 | Oncogenic | (103) | |
| lncRNA MIAT | Upregulation | MiR-29a-3p, HDAC4 | Oncogenic | (104) | |
| lncRNA GATA6-AS1 | Downregulation | Histone methylation | FZD4 | Tumor suppressor | (105) |
| LINC01446 | Downregulation | RASD1 | Tumor suppressor | (106) | |
| lncRNA PART1 | Downregulation | PLZF, PDGFB | Tumor suppressor | (107) | |
| lncRNA ARHGAP27P1 | Downregulation | P15, P16, P57 | Tumor suppressor | (108) | |
| lncRNA HOXD-AS1 | Upregulation | PDCD | Oncogenic | (109) | |
| lncRNA HOXA11-AS | Upregulation | PRSS8, KLF2, P21 | Oncogenic | (110) | |
| lncRNA FEZF1-AS1 | Upregulation | P21 | Oncogenic | (111) | |
| lncRNA linc01503 | Upregulation | DUSP5, CDKN1A | Oncogenic | (112) | |
| lncRNA FOXP4-AS1 | Upregulation | EZH2, LSD1 | Oncogenic | (108) | |
| LINC00461 | Upregulation | LSD1 | Oncogenic | (113) | |
| lncRNA PCAT1 | Upregulation | PTEN | Oncogenic | (114) | |
| lncRNA ANR1L | Upregulation | PLZF | Oncogenic | (115) | |
| lncRNA HOTTIP | Upregulation | IGFBP3 | Oncogenic | (116) | |
| lncRNA HOTAIR | Upregulation | miR34a | Oncogenic | (117) | |
| lncRNA HOXA13 | Upregulation | BMP7 | Oncogenic | (118) | |
| lncRNA CASC15 | Upregulation | CDKN1A | Oncogenic | (119) | |
| LINC00673 | Upregulation | KLF2, LAST2 | Oncogenic | (120) | |
| LINC01436 | Upregulation | miR-585-3P | Oncogenic | (121) | |
| lncRNA FOXD2-AS1 | Upregulation | EphB3 | Oncogenic | (122) | |
| lncRNA lncHEIH | Upregulation | GSDME | Oncogenic | (123) | |
| LINC00152 | Upregulation | P15, P21 | Oncogenic | (124) | |
| lncRNA GClnc1 | Upregulation | Histone acetylation, methylation | SOD2 | Oncogenic | (125) |