Table 3.
ncRNAs regulated by histone modification in EC.
| ncRNA | Expression | Mechanism | Target | Function | Reference |
|---|---|---|---|---|---|
| miR-142-5p | Upregulation | Histone demethylation | CD9 | Oncogenic | (136) |
| miR-155 | Upregulation | Histone acetylation | SOX1 | Oncogenic | (137) |
| miR-454 | Upregulation | Histone deacetylation | CHD5 | Oncogenic | (138) |
| miR-34a | Downregulation | Histone deacetylation | CD44 | Tumor suppressor | (139, 140) |
| miR-330-3p | Downregulation | Histone deacetylation | MSI1 | Tumor suppressor | (141) |
| miR-375 | Downregulation | Histone deacetylation | YAP1, TEAD4, CTGF | Tumor suppressor | (142) |
| miR-454 | Upregulation | Histone deacetylation | CHD5 | Oncogenic | (138) |
| miR-133 | Downregulation | Histone deacetylation, | mcl-1, Bcl-xL | Tumor suppressor | (143) |
| HOXC-AS3 | Upregulation | Histone methylation, Histone acetylation | MMP7, WNT10B, HDAC5 | Oncogenic | (144) |
| lncRNA FENDRR | Downregulation | Histone deacetylation | FN1, MMP2, MMP9 | Tumor suppressor | (145) |
| lncRNA HRCEG | Downregulation | Histone deacetylation | – | Tumor suppressor | (145) |