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. 2022 Feb 1;98(5):e470–e482. doi: 10.1212/WNL.0000000000013165

Figure 5. MR Analyses Assessing the Effects of Low mtDNA-CN (and Blood Cell Traits) on 3-Month Post–Ischemic Stroke Prognosis.

Figure 5

Genetic predisposition to low mitochondrial DNA copy number (mtDNA-CN), but not blood cell counts, is associated with higher risk of 3-month outcomes after stroke. Effect estimates for mtDNA-CN are expressed per 1-SD decrease in genetically predicted mtDNA-CN, whereas those for blood cell traits were expressed per 1-SD increase in genetically predicted blood cell counts (or neutrophil-to-lymphocyte ratio). Causal effect estimates obtained by the inverse variance–weighted method are displayed because no significant heterogeneity or directional pleiotropy was detected for any analysis (eTables 9 and 10, links.lww.com/WNL/B699). CI = confidence interval; mRS = modified Rankin Scale.