Skip to main content
. 2022 Feb 1;98(5):e483–e492. doi: 10.1212/WNL.0000000000013129

Figure 1. Overview of the 2-Stage Discovery–Validation Framework in 3 Independent Datasets: The Nurses' Health Study (NHS), Nurses' Health Study 2 (NHS2), and Prevención con Dieta Mediterránea (PREDIMED) Studies.

Figure 1

Four metabolites (N6-acetyl lysine, methionine sulfoxide, glucuronate, and sucrose) met the threshold for validation in either NHS2 or PREDIMED.