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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Free Radic Biol Med. 2021 Dec 9;178:347–359. doi: 10.1016/j.freeradbiomed.2021.12.012

Figure 2. Metabolism of γT -.

Figure 2.

γT is metabolized by CYP4F2-catalyzed ω-hydroxylation and ω-oxidation to form 13’-OH and 13’-COOH. 13’-COOH is further metabolized via β-oxidation to generate shorter-chain carboxychromanols and terminal metabolite, γ-CEHC. Studies in animal and humans show that 13’-COOH appears to be the most abundant metabolite found in feces, and γ-CEHC and conjugated γ-CEHC are the major metabolites in the blood and urine.