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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Nat Protoc. 2021 Jul 7;16(8):4031–4067. doi: 10.1038/s41596-021-00575-5

Figure 12. Absence of biological overlap between datasets leads to almost random performance and lack of hierarchical cell type structure.

Figure 12.

a Anticipated result: AUROC heatmap with inhibitory neuron cell types as query (rows) and inhibitory neuron cell types as reference (columns). b Possible issue: same as a, but with non-neuronal cell types as reference (columns). The heatmap lacks clear replicating clusters (dark red rectangles) and known secondary biological relationships (e.g., similarity of CGE-derived interneurons Vip, Sncg on the query side).