Table 3.

Rotarix IgA seroconversion with and without abstention from breastfeeding at the time of vaccination^a.

Reference	Location	Income groupd	Vaccine	RV1 IgA seroconversion post dose 2		p-Value
				Withholding breastfeedingb	Non-withholding breastfeedingc
Rongsen-Chandola et al. 2014 [55]	India	LM	RV1	26%	27%	NS
Ali et al. 2015 [61]	Pakistan	LM	RV1	28%	38%	NS
Groome et al. 2014 [60]	South Africa	UM	RV1	63%	58%	NS

SC: seroconversion, RV1: Rotarix, NS: Non-statistically significant (p > 0.05).

^aPost licensure randomized control trials.

^bAbstention from breastfeeding for at least 30 or 60 min before and after each dose or Rotarix.

^cUnrestricted breastfeeding was encouraged.

^dWorld Bank list of economies (December 2016) low-income (L); lower middle-income (LM); upper middle-income (UM); high-income (H).