. Author manuscript; available in PMC: 2022 Feb 9.

Published in final edited form as: Expert Rev Vaccines. 2017 Dec 29;17(2):145–161. doi: 10.1080/14760584.2018.1418665

Table 5.

Gut microbiome and concomitant intestinal infections by Rotarix IgA seroconversion.

Reference	Location	Income group^a	Vaccine	No of Doses	Measured factors	RV vaccines IgA seroconversion		p-Value
Reference	Location	Income group^a	Vaccine	No of Doses	Measured factors	R	NR	p-Value
Harris et al. 2016 [114]	Ghana	LM	RV1	2	Pre dose 1 fecal microbiome composition, correlation	Streptococcus bovis (FDR = 0.008)	Bacteroidetes phylum (FDR = 0.003)	-
Harris et al. 2017 [117]	Pakistan	LM	RV1	2/3	Pre dose 1 fecal microbiome composition, correlation	Clostridium, (p = 0.02) Proteobacteria (p = 0.04)
Taniuchi et al. 2016 [115]	Bangladesh	LM	RV1	2	Pre dose 1 fecal enterovirus quantity, OR (95% CI)	0.78 (0.64–0.96)		0.022
Clark et al. 2016 [116]	Ecuador	UM	RV1	2	Maternal antenatal helminth infections, OR (95% CI)	1.31 (1.06–1.59)		0.011

R: responders; NR: non responders; IQR: interquartile range; OR: odds ratio; FDR: false discovery rate; RV1: rotarix.

World Bank list of economies (December 2016) low-income (L); lower middle-income (LM); upper middle-income (UM); high-income (H).