Table 7.
Rotavirus vaccine response in infants with and without undernutrition.
| Reference | Location | Income groupc | Vaccine | No of Doses | Measured outcomes | Undernurished |
p-Value | |
|---|---|---|---|---|---|---|---|---|
| Yes | No | |||||||
| Protection against severe RVGE | ||||||||
| Gastanaduy et al. 2016 [35] | Botswanaa | UM | RV1 | 2 | Effectiveness after 1 or 2 years (95% CI) | −28 (−309, 60) | 75 (41, 89) | 0.02 |
| Gruber et al. 2017 [49] | Ghana, Kenya and Malib | L, LM | RV5 | 3 | Efficacy after 1 year (95% CI) | 33 (−64, 73) | 72 (48, 85) | NS |
| Efficacy after 2 years (95% CI) | 7 (−83, 53) | 44 (24, 59) | NS | |||||
| Gruber et al. 2017 [49] | Bangladesh and Vietnamb | LM | RV5 | 3 | Efficacy after 1 year (95% CI) | 66 (−229, 96) | 50 (11, 72) | NS |
| Efficacy after 2 years (95% CI) | 23 (−245, 83) | 50 (24,66) | NS | |||||
| Perez-Schael et al. 2007 [137] | Brazil, Mexico, Venezuelab | UM | RV1 | 2 | Efficacy after 1 year (95% CI) | 73 (11, 92) | 74 (52, 86) | NS |
| Immunogenicity | ||||||||
| Emperador et al. 2016 [75] | Bangladesha | LM | RV1 | 2 | IgA seroconversion rate | 55% | 57% | NS |
R: responders; NR: non responders; NS: non-statistically significant (p > 0.05); RV1: rotarix; RV5: rotateq.
a
Undernutrition was defined as a weight-for-length z score <−2 based on World Health Organization growth standards.
b
Undernutrition was defined as a weight-for-age z score <−2 based on World Health Organization growth standards.
c
World Bank list of economies (December 2016) low-income (L); lower middle-income (LM); upper middle-income (UM); high-income (H).