Table 1.
Cohort Characteristics
| Absolute increase in 25(OH)D between day 0 and day 3 | ||||||
|---|---|---|---|---|---|---|
| Characteristic | <0.0 ng/ml | 0.0–3.14 ng/ml | 3.15–16.40 ng/ml | > 16.40 ng/ml | Total | P-value |
| No. (%) | 105 | 109 | 107 | 107 | 428 | |
| Age Mean (SD) | 62.7 (14.7) | 65.9 (12.7) | 64.6 (14.6) | 63.4 (17.3) | 64.2 (14.9) | 0.42* |
| Female Sex No. (%) | 38 (36.2) | 36 (33.0) | 36 (33.6) | 41 (38.3) | 151 (35.3) | 0.84 |
| Day 0 25(OH)D Mean (SD) | 14.6 (4.6) | 12.5 (4.8) | 12.3 (4.2) | 13.3 (4.7) | 13.2 (4.6) | 0.001* |
| SAPS II Mean (SD) | 31.3 (13.4) | 35.1 (14.7) | 33.6 (15.9) | 33.4 (17.2) | 33.4 (15.4) | 0.34* |
| CRP Day 0 Mean (SD) | 116.5 (86.1) | 128.7 (83.7) | 137.8 (90.2) | 116.2 (98.0) | 124.9 (89.8) | 0.23* |
| Total Bilirubin Day 0 Mean (SD) | 1.8 (4.1) | 1.5 (1.8) | 2.0 (2.4) | 1.0 (1.5) | 1.6 (2.6) | 0.026* |
| Creatinine Day 0 Mean (SD) | 1.5 (1.2) | 1.4 (1.0) | 1.5 (1.0) | 1.2 (0.8) | 1.4 (1.0) | 0.036* |
| Vitamin D3 Intervention No. (%) | 18 (17.1) | 17 (15.6) | 70 (65.4) | 107 (100) | 212 (49.5) | <0.001 |
| ICU | <0.001 | |||||
| Anesthesia ICU No. (%) | 28 (26.7) | 22 (20.2) | 16 (15.0) | 17 (15.9) | 83 (19.4) | |
| Cardiac Surgery ICU No. (%) | 27 (25.7) | 40 (36.7) | 39 (36.5) | 20 (18.7) | 126 (29.4) | |
| Surgical ICU No. (%) | 5 (4.8) | 3 (2.8) | 10 (9.4) | 5 (4.7) | 23 (5.4) | |
| Medicine ICU No. (%) | 27 (25.7) | 20 (18.4) | 22 (20.6) | 21 (19.6) | 90 (21.0) | |
| Neurological ICU No. (%) | 18 (17.1) | 24 (22.0) | 20 (18.7) | 44 (41.1) | 106 (24.8) | |
| 28-day Mortality No. (%) | ||||||
| Analytic Cohort (N=428) | 28 (26.7) | 29 (26.6) | 29 (27.1) | 9 (8.4) | 95 (22.2) | 0.001 |
| Baseline 25(OH)D ≤ 12 ng/ml (N=181) | 13 (40.6) | 18 (36.0) | 12 (23.5) | 4 (8.3) | 47 (26.0) | 0.003 |
Note: Data presented as n (%) unless otherwise indicated. P values determined by chi-square unless designated by (*) then P value determined by ANOVA