TABLE 1.
Baseline Characteristics of the Neonates at Enrollment
| Characteristics | Cohort 1A (N = 9) | Cohort 1B (N = 9) | Total (N = 18) | |
| Sex (female: male) | 6 (67%): 3 (33%) | 7 (78%): 2 (22%) | 13 (72%): 5 (28%) | |
| Ethnicity | Black | 9 (100%) | 8 (89%) | 17 (94%) |
| Mixed race | 0 (0%) | 1 (11%) | 1 (6%) | |
| Gestational age at birth (wk) | 39 (39–39) | 39 (39–40) | 39 (39–40) | |
| Birth weight (g) | 3090 (2840–3240) | 3195 (2955–3475) | 3143 (2890–3475) | |
| Days of life | 3 (2–4) | 2 (2–2) | 2 (2–3) | |
| Weight (g) | 3010 (2750–3140) | 3005 (2840–3355) | 3008 (2770–3355) | |
| Length (cm) | 47 (47–48) | 48 (48–50) | 48 (47–49) | |
| Primary caregiver | Mother | 9 (100%) | 9 (100%) | 18 (100%) |
| Age of primary caregiver (yr) | 30 (27–33) | 32 (28–34) | 31 (27–34) | |
| ARV prophylaxis | NVP | 4 (44%) | 3 (33%) | 7 (39%) |
| NVP + ZDV | 5 (56%) | 6 (67%) | 11 (61%) | |
| Hemoglobin (g/dL) | 17.6 (16.2–18.2) | 17.3 (17.1–19.0) | 17.5 (16.3–18.4) | |
| Sodium (mmol/L) | 143 (139–144) | 140 (138–142) | 142 (139–144) | |
| Potassium (mmol/L) | 5.2 (4.7–5.3) | 5.1 (5.0–5.4) | 5.2 (4.8–5.4) | |
| Creatinine (µmol/L) | 51 (49–63) | 68 (57–69) | 58 (51–69) | |
| ALT (U/L) | 11 (8–14) | 10 (8–11) | 11 (8–13) | |
| AST (U/L) | 54 (31–59) | 53 (50–58) | 54 (46–59) | |
| Total bilirubin (µmol/L) | 72 (30–106) | 61 (29–72) | 69 (29–79) | |
| Heart rate* (beats/min) | 143 (120–150) | 129 (120–140) | 132 (120–150) | |
| QT interval* (msec) | 280 (240–280) | 280 (248–300) | 280 (248–288) | |
| QTcF1 (msec) | 346 (331–363) | 364 (340–378) | 356 (331–365) | |
| HIV-1 NAT | Negative | 9 (100%) | 9 (100%) | 18 (100%) |
Values are n (%) or median (interquartile range).
*
As assessed by pediatric cardiologist.
ALT, alanine aminotransferase; ARV, antiretroviral; g, grams; HIV-1 NAT, HIV-1 nucleic acid test; QTcF, QT interval according to Fridericia formula.