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. 2022 Jan 26;9:806966. doi: 10.3389/fmolb.2022.806966

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Copyright © 2022 Ren, Chen, Nie, Qu, Ju and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ranolazine attenuates altered cardiac function in diabetic rats. (A–D) T-CHO, TG, LDL-C and HDL-C were measured at 0 and 8 weeks in animals fed a high-fat diet. (E) Changes in fasting blood glucose levels were assayed every 4 weeks in all groups of rats. (F) M-mode echocardiogram of the left ventricle. (G) The LVEF and LVFS of all groups are shown. ^*** p < 0.001 vs. 0 weeks, ^*** p < 0.001 vs. control, ^### p < 0.001 vs. DM; n = 6-10.