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. 2022 Jan 26;9:806966. doi: 10.3389/fmolb.2022.806966

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Copyright © 2022 Ren, Chen, Nie, Qu, Ju and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ranolazine weakens cardiac fibrosis in diabetic rats. (A) Comparison of H&E and Masson staining among the groups. Scale bar = 20 μm. (B,C) Immunohistochemistry staining for TGF-β1, collagen I and collagen III. Scale bar = 20 μm. (D) Real-time PCR assay of the relative mRNA expression of TGF-β1, collagen I and collagen III. (E) Western blot assay of the relative protein expression of TGF-β1, collagen I and collagen III. ^*** p < 0.001 vs. control, ^# p < 0.05 vs. DM, ^## p < 0.01 vs. DM, ^### p < 0.001 vs. DM; n = 6.