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. 2022 Jan 26;9:806966. doi: 10.3389/fmolb.2022.806966

FIGURE 3.

FIGURE 3

Ranolazine inhibits pyroptosis in diabetic rat cardiac tissues. (A–D) Immunohistochemical detection of caspase-1, IL-1β and GSDMD expression in cardiac tissues of rats in the groups. Scale bar = 20 μm. (E,F) Real-time PCR assay of relative mRNA expression of caspase-1 and IL-1β in cardiac tissues of rats in groups. (G–I) Western blot assay of relative protein expression of caspase-1, IL-1β and GSDMD proteins in cardiac tissues of rats in groups. ** p < 0.01 vs. control, *** p < 0.001 vs. control, # p < 0.05 vs. DM, ### p < 0.001 vs. DM; n = 6.