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. 2022 Feb 9;20:56. doi: 10.1186/s12916-022-02254-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A PPT diet improves metabolic outcomes after 6 months. Illustration of changes in multiple metabolic outcomes across all participants and per participant. Left: changes in the outcomes across all participants (n = 16), presented as the 95% confidence interval (CI) of the change in outcomes at 6 months time point vs. baseline. Statistical significance is marked (one-sample t-test for all parameters except for HOMA-IR, which we used the Mann-Whitney U test, ***p < 0.001, **p < 0.01, *p < 0.05; n.s, not significant). Right: changes in the outcomes per participant, presented with a waterfall-like scheme, where each bar represents a participant. The color scale refers to bars, indicating the level of baseline value of each outcome for each participant. Participants are sorted by the 6-month change in HbA1c