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. 2022 Feb 9;21:42. doi: 10.1186/s12943-022-01527-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Evaluation of the circRNA panel based on tumor histology, pre vs. post-surgery specimens and their expression in GC vs. other gastrointestinal cancers. A The diagnostic performance of biomarker panel according to tumor histology (diffuse and intestinal type) in both serum training and validation cohorts. B Expression of candidate circRNAs in pre- and post-surgery serum specimens from a prospective cohort of GC patients. C Assessment of risk probability based on risk prediction formula between pre-and post-surgery GC specimens. D Performance of liquid biopsy based circRNAs biomarker panel across different GI malignancies (gastric cancer, GC; colorectal cancer, CRC; pancreatic ductal adenocarcinoma, PDAC; esophageal squamous cell carcinoma, ESCC; hepatocellular cancer, HCC)