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. 2022 Jan 26;13:837977. doi: 10.3389/fimmu.2022.837977

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Copyright © 2022 Hua, Wang, Fan, An, Li, Song, Kong, Li and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CFA-induced inflammatory pain and paw inflammation was attenuated by JQ1, the BRD4 inhibitor. (A) Experimental design to test the antinociceptive effects of BRD4 inhibitor JQ1 in the CFA-induced inflammatory pain model. (B, C) Effects of BRD4 inhibitor JQ1 on thresholds of mechanical allodynia (B) and thermal hyperalgesia (C). Tests were carried out before CFA injection and on days 1, 3,and 7, n=6 mice/group. (D) Inflammation in mouse paw tissues by H&E staining, n=3 mice/group, all figures were magnified by 400×. Data were presented as mean ± standard deviation (SD). (**P < 0.01, ***P < 0.001).