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. 2022 Jan 26;13:837977. doi: 10.3389/fimmu.2022.837977

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Copyright © 2022 Hua, Wang, Fan, An, Li, Song, Kong, Li and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The BRD4 inhibitor JQ1 attenuates neuronal pyroptosis in vitro. (A) Pyroptosis-related proteins were tested by western blot in HT22 cells stimulated with LPS (1 μg/mL) for 12h, 24h and ATP (5 mM) for 30 min. (B) Viability of HT22 cells with different concentrations of JQ1, n = 3 per group. (C) Western blot analysis of pyroptosis-related proteins expression in HT22 cells treated by LPS (1 μg/mL) for 24h and ATP (5 mM) for 30 min with or without different concentrations of JQ1. (D, E) Semiquantitative analysis of NLRP3 and GSDMD-N. Data are presented as mean ± standard deviation (SD) of three independent experiments. (**P < 0.01, ***P < 0.001).