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BRD4 knockdown attenuates LPS and ATP-induced HT22 cells pyroptosis. (A) Western blot tested NLRP3, GSDMD-F and GSDMD-N in HT22 cells transfected si-RNA targeting BRD4 for 48 h and then stimulated with LPS (1 μg/mL) and ATP (5 mM) for 30 min. (B–E) Semiquantitative analysis of NLRP3, GSDMD-F, GSDMD-N and P-P65. Data are presented as mean ± standard deviation (SD) of three independent experiments. (*P < 0.05, ***P < 0.001).
