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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nature. 2021 Jun 30;595(7867):455–459. doi: 10.1038/s41586-021-03691-0

Extended Data Fig. 6 |. PAM and NAM models and TM6-TM6 interfaces in cryo-EM densities.

Extended Data Fig. 6 |

a, Etelcalcetide model in cryo-EM density. b, Active-state CaSR TM6-TM6 interface model in cryo-EM density (shown here is CaSR-cinacalcet. The TM6-TM6 interface of CaSR-evocalcet-etelcalcetide is highly similar). c, Cinacalcet models in cryo-EM densities. d, Evocalcet models in cryo-EM densities. e, NAM model in cryo-EM density for the CaSR-NAM-Ca2+-Trp complex. f, CaSR-NAM-Ca2+-Trp complex TM6-TM6 interface model in cryo-EM density. g, Inactive-state NAM binding pocket. h, Inactive-state NAM model in cryo-EM density.