Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nature. 2021 Jun 30;595(7867):455–459. doi: 10.1038/s41586-021-03691-0

Extended Data Fig. 7 |. Binding modes of cinacalcet and evocalcet.

Extended Data Fig. 7 |

a, Interaction network in the CRD-ECL2-ECL3 region of cinacalcet-bound active-state CaSR. b, Chemical structures of evocalcet and cinacalcet. c, Structure of active-state CaSR 7TMs complexed with evocalcet. Similar to cinacalcet (Fig. 3a), evocalcet adopts an extended conformation in 7TMA (green) and a bent conformation in 7TMB (blue), making distinct interactions with the two protomers.