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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nature. 2021 Jun 30;595(7867):455–459. doi: 10.1038/s41586-021-03691-0

Fig. 2 |. Asymmetric configuration of active-state CaSR 7TMs and interactions between the CRD and the 7TMs.

Fig. 2 |

a, Overall conformation of the asymmetric 7TMs. b, Ribbon view of the asymmetric TM6–TM6 interface (boxed region in a). c, Interaction network in the CRD–ECL2–ECL3 region of active-state CaSR, showing the conformations of 7TMA with an extended PAM and 7TMB with a bent PAM.