Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nature. 2021 Jun 30;595(7867):455–459. doi: 10.1038/s41586-021-03691-0

Fig. 4 |. Symmetric configuration of CaSR–NAM–Ca2+–Trp 7TMs and the TM6 toggle switch.

Fig. 4 |

a, Overall structure of the symmetric CaSR–NAM–Ca2+–Trp 7TMs. b, Comparison of the symmetric CaSR–NAM–Ca2+–Trp 7TMs (grey) and the asymmetric PAM-bound 7TMs (7TMA (green) and 7TMB (blue)) based on 7TMB alignment. c, Conformational changes in CaSR TM6. d, Conformational changes in the 5HT2A serotonin receptor (Protein Data Bank (PDB): 6A94 and 6WHA), a family A GPCR that couples to Gq in a similar way to CaSR. e, Sequence logo analysis of family C and family A TM6 regions highlighting the conservation of toggle switch motif residues.