Table 2.

Independent Prognostic Value of a Subset of Commonly Mutated Genes Using Multivariate Analysis and Multiple Comparisons (N = 185)

	Progression-Free Survival				Overall Survival
Gene mutation	P	FDR-adjusted P value	HR	95% CI	P value	FDR-adjusted P value	HR	95% CI
A
CDKN2A	.0950	.3837	1.40	0.94–2.07	.0215	.0430	1.57	1.07–2.32
CDKN2B	.1960	.3847	1.28	0.88–1.85	.0039	.0120	1.74	1.19–2.53
EGFR	.1648	.3847	1.30	0.90–1.88	.0010	.0100	1.85	1.28–2.68
NF1	.2656	.3847	1.29	0.82–2.03	.4850	.5389	0.85	0.53–1.35
PDGFRA	.9788	.9788	1.01	0.54–1.88	.7427	.7427	1.10	0.61–1.99
PIK3CA	.5273	.6292	1.18	0.70–2.00	.3403	.4254	1.28	0.77–2.12
PTEN	.5663	.6292	0.90	0.62–1.29	.0295	.0492	0.66	0.46–0.96
TERT promoter	.1151	.3837	1.63	0.89–2.99	.0048	.0120	2.49	1.32–4.70
TP53	.2693	.3847	0.80	0.54–1.19	.2097	.2996	0.77	0.52–1.16
IDH1/2	.0171	.1710	0.33	0.14–0.82	.0044	.0120	0.12	0.03–0.52
Covariates: age, KPS, adjuvant chemoradiation, MGMT promoter methylation, EOR
B
CDKN2A	.1307	.6304	1.35	0.91–2.00	.0320	.0720	1.53	1.04–2.26
CDKN2B	.2154	.6304	1.26	0.87–1.83	.0028	.0185	1.78	1.22–2.61
EGFR	.3467	.6304	1.20	0.82–1.73	.0062	.0186	1.67	1.16–2.42
NF1	.3502	.6304	1.24	0.79–1.95	.3586	.5379	0.80	0.51–1.28
PDGFRA	.9915	.9915	1.00	0.54–1.87	.7030	.7030	1.12	0.62–2.02
PIK3CA	.5504	.8033	1.17	0.69–1.99	.4359	.5604	1.23	0.73–2.04
PTEN	.2441	.6304	0.80	0.56–1.16	.0041	.0185	0.58	0.40–0.84
TERT promoter	.6248	.8033	1.18	0.62–2.25	.1234	.2221	1.67	0.87–3.22
TP53	.7233	.8137	0.93	0.62–1.40	.6888	.7030	0.92	0.62–1.37
Covariates: age, KPS, adjuvant chemoradiation, MGMT promoter methylation, EOR, IDH1/2 mutation

Bolded values indicate P < .05.