FIG 4.

Expression of sncRNA1 and 2 increases HVEM promoter activity. 293T cells were transfected with pGL4-pHVEM and plasmids containing LAT, WT sncRNA1, WT sncRNA2, or empty vector (A), WT sncRNA1, sncRNA1 deletion plasmid (ΔsncRNA1), or empty vector (B), or WT sncRNA2, sncRNA2 deletion plasmid (ΔsncRNA2), or empty vector (C). HVEM promoter activity was measured 8, 24, and 48 h posttransfection. Expression relative to the empty vector is shown as fold change. Each point represents the mean ± SEM (n = 10 for A, n = 6 for B, C) from three separate experiments. *, P < 0.002.