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Deletion of both sncRNA1 and sncRNA2 sequences results in loss of HVEM promoter activity. 293T cells were transfected with pGL4-pHVEM and LAT or sncRNA1 and sncRNA2 deletion plasmid (ΔsncRNA1&2). The effects on HVEM promoter activity were determined 8, 24, and 48 h posttransfection. *, P < 0.0001.
