FIG 5.
Comparison of 4pox DNA vaccine immunogenicity when delivered by multiple platforms in rabbits. (A) Experimental design. Four groups of rabbits (n = 3) were vaccinated three times at 1-month intervals (black arrows) with 4pox DNA by i.m. EP, i.d. needle/syringe, and the DSJI i.d. or i.m. device. Serum was collected at weeks 0, 4, 6, 8, and 10 (red arrows). (B) Protein-specific ELISAs were performed as in Fig. 2B (C) PRNT50s were determined with serum from the indicated group at the indicate time point as described in Fig. 2C. Geometric mean titers and standard deviations are shown.