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. Author manuscript; available in PMC: 2022 Feb 9.
Published in final edited form as: Nat Rev Microbiol. 2010 Oct 12;8(11):827–834. doi: 10.1038/nrmicro2437

Figure 3 |. The principle of slow drug release with nanoparticles.

Figure 3 |

The kinetics of the accumulation of rifampicin (RIF), pyrazinamide (PZA) and isoniazid (INH) in the sera of guinea pigs after drug administration in the free form or using drug-enclosed poly-(lactic-co-glycolic acid) (PLGA) nanoparticles. a | Drugs administered through the oral route. b | Drug administration through the aerosol (lung) route. Note the substantial extension of the elevated drug concentration in the plasma after the administration of drugs using the nanoparticle system. These levels are significantly higher than the minimum inhibitory concentration (MIC) of the antibiotics when used to treat Mycobacterium tuberculosis. Data from REF. 27.