Fig. 2.

Structural overview of E484A and N501Y/Y505H mutational impact on P2B-2F6 and S2-H14 antibody interaction of Omicron variant. a Overview of P2B-2F6 complexed with RBD (PDB: 7BWJ). The P2B-2F6 is presented in a red cartoon, and the RBD is presented on a light blue surface with a red footprint. b The footprint of key residues on RBD interacting with P2B-2F6. The key residue names are marked beside, and the mutated residue E484 is colored in red. c Zoom view of wild type (E484) and mutant (A484) structure of RBD with P2B-2F6. Critical residues participating in the interaction between RBD and P2B-2F6 are presented in the sticks, and the polar bond is presented as dashed green lines. For mutant structure, the residue from antibody excluded from the polar interaction due to A484 mutation is colored in gray. d Overview of S2-H14 in complex with RBD (PDB:7JX3). The S2-H14 is presented in a yellow cartoon, and the RBD is presented on a light blue surface with a yellow footprint. e The footprint of key residues on RBD interacting with S2-H14. The key residue names are marked beside, and the mutated residues N501/Y505 are colored in red. f Zoom view of wild type (N501/Y505) and mutant (Y501/H505) structure of RBD with S2-H14. Critical residues participating in the interaction between RBD and S2-H14 are presented in the sticks, and the polar bond is presented as dashed green lines. For mutant structure, the residues from antibody excluded from the polar interaction due to Y501/H505 mutation are colored in gray