Fig. 4.

Immune escape profile of SARS-CoV-2 variants determined by pseudovirus neutralization assay with the indicated antibodies. The antibody neutralization efficacy is presented as a heatmap colored in a red-to-green gradient. The neutralizing concentration log₁₀(IC₅₀) [log₁₀(µg/mL)] value is listed in the table. A deeper red represents a stronger neutralization ability of the indicated antibody for the pseudovirus expressing the indicated spike protein, and a deeper green represents a lower neutralization ability. The change of neutralization efficacy (∆neutralizing concentration) [log₁₀(µg/mL)] due to mutations in the spike protein is presented as a heatmap colored in a pink-to-blue gradient. A deeper pink color represents a larger increase in neutralization ability than the wild type, and a deeper blue represents a larger decrease in neutralization ability. The IC₅₀ values of each antibody toward the indicated pseudoviruses shown in the heatmap are the average results from duplicate experiments