TABLE 4.
Associations of early pregnancy serum ferritin with hypertensive disorder of pregnancy, gestational hypertension and preeclampsia (n = 5834)1
| Gestational Hypertensive Disorder | Gestational hypertension | Preeclampsia | ||||
|---|---|---|---|---|---|---|
| Early pregnancy serum ferritin | OR (95% CI) | n cases | OR (95% CI) | n cases | OR (95% CI) | n cases |
| Quintile 12, 2–26 μg/L | 0.85 (0.57–1.27) | 46 | 0.86 (0.52–1.44) | 26 | 0.84 (0.45–1.55) | 20 |
| Quintile 22, 26–42 μg/L | 1.10 (0.77–1.57) | 67 | 0.95 (0.60–1.52) | 35 | 1.36 (0.80–2.34) | 32 |
| Quintile 3, 42–63 μg/L | reference | 69 | reference | 44 | reference | 25 |
| Quintile 42, 63–96 μg/L | 0.85 (0.60–1.21) | 67 | 0.90 (0.59–1.39) | 47 | 0.75 (0.41–1.37) | 20 |
| Quintile 52, 96–390 μg/L | 1.20 (0.86–1.66) | 102 | 1.35 (0.91–2.01) | 76 | 0.94 (0.54–1.65) | 26 |
| SDS3 | 1.08 (0.96–1.22) | 351 | 1.15 (0.99–1.34) | 228 | 0.98 (0.81–1.18) | 123 |
Models are adjusted for maternal age, ethnicity, educational level, parity, prepregnancy BMI, folic acid supplementation, smoking, gestational age at time of blood sampling, and CRP levels. CRP, C-reactive protein; SDS, standard deviation score.
Values are ORs (95% CIs) that reflect differences in risks of gestational hypertensive disorder, gestational hypertension, and preeclampsia per serum ferritin quintile. Groups are compared to women in quintile 3 (serum ferritin: 42 μg/L–63 μg/L) as the reference. Estimates are from multiple imputed data.
Values are ORs (95% CIs) that reflect differences in risks of gestational hypertensive disorder, gestational hypertension, and preeclampsia per log serum ferritin as SDS.