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. 2022 Feb 9;10(1):e01860-21. doi: 10.1128/spectrum.01860-21

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Copyright © 2022 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 10 — Model depicts the involvement of HSPA8 in PRRSV attachment and internalization. HSPA8 functions as a co-factor for PRRSV infection. In detail, HSPA8 is involved in PRRSV attachment and internalization via CME along with PRRSV indispensable receptor CD163. Interference with the interaction between HSPA8 and PRRSV on the cell surface inhibits viral infection in host cells by HSPA8 pAbs and soluble HSPA8 protein. In addition, PRRSV internalization is impaired by HSPA8 ATPase inhibitors VER155008 and apoptozole.