FIG 5.

The fingertips loops of several RdRp polymerases. The B-factor maps for (A) Machupo virus (MACV, PDB 6KLD) (61), (B) Lassa Virus (LASV, PDB 6KLC), (C) Influenza C (FluC, PDB 5D98) (62), (D) La Crosse encephalitis virus (LACV) (PDB 6Z8K) (21), (E) RVFV L. (A, B, E) Fingertips are conservative, while FluC’s and LACV’s fingertips are unstable, and their RNA synthesis initiation requires 5′ vRNA. (F) Interaction of residues between fingertips and finger extension. The residue on the fingertips and the finger extension are colored green and yellow, respectively.