Representative traces of ICP in response to electrostimulation of the cavernous nerve at 0.75, 1, 2, 4, 6, and 10mA current for (A) lean rats treated with blank-np, (B) Diabetic ZDF treated with blank-np, and (C) Diabetic ZDF treated with curc-np. The lean rats exhibited high ICP response to electrostimution, not seen in the ZDF fatty animals; this loss was recovered in the curc-np treated ZDF fatty rats. (D) Shows a representative trace of systemic BP (BP was not significantly different between the different groups of animals). The average ICP/BP ratio is shown for 0.75 mA (E) and for all level of stimulation (F), demonstrating improvement in erectile function in ZDF rats treated with curc-np (*P<0.05; **P <0.01).