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. 2022 Feb 8;13:735. doi: 10.1038/s41467-022-28039-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a–d Plasma glucose concentration (mM) after a 4-h fast in control, βInsr^HET, and βInsr^KO LFD-fed female (black, light pink, dark red bars; n_7week = 15, 20, 14; n_16week = 9, 7, 12; n_28week = 9, 12, 10; n_31week = 2, 9, 5; n_36week = 9, 12, 10; n_44week = 7, 5, 10) and male (black, light blue, dark blue bars; n_7week = 15, 20, 14; n_16week = 9, 7, 12; n_28week = 9, 12, 10; n_31week = 2, 9, 5; n_36week = 9, 12, 10; n_44week = 7, 6, 10) as well as HFD-fed female (black, bright pink, purple bars; n_7week = 13, 12, 10; n_11week = 13, 14, 12; n_16week = 10, 13, 8; n_21week = 14, 18, 12; n_28week = 12, 14, 11; n_31week = 12, 14, 12; n_36week = 12, 13, 12; n_44week = 6, 8, 7; n_50week = 10, 12, 11; n_54week = 10, 11, 11) and male (black, bright green, dark green bars; n_7week = 8, 13, 10; n_11week = 8, 15, 10; n_16week = 8, 13, 10; n_21week = 8, 15, 10; n_28week = 8, 15, 10; n_31week = 8, 14, 10; n_36week = 7, 13, 10; n_44week = 5, 9, 4; n_50week = 6, 10, 9) mice. e–h Longitudinally tracked body mass (g) in control, βInsr^HET, and βInsr^KO LFD-fed female (black, light pink, dark red bars; n_4week = 18, 36, 14; n_7week = 16, 18, 12; n_11week = 19, 18, 12; n_16week = 8, 20, 14; n_21week = 6, 4, 7; n_28week = 9, 10, 10; n_31week = 3, 7, 5; n_36week = 9, 12, 10; n_40week = 7, 7, 9; n_44week = 7, 6, 9) and male (black, light blue, dark blue bars; n_4week = 19, 33, 17; n_7week = 14, 22, 11; n_11week = 13, 22, 10; n_16week = 6, 14, 7; n_21week = 6, 11, 7; n_28week = 8, 13, 7; n_31week = 8, 5, 3; n_36week = 8, 13, 7; n_40week = 8, 13, 7; n_44week = 8, 13, 4) as well as HFD-fed female (black, bright pink, purple bars; n_7week = 13, 12, 8; n_11week = 17, 17, 12; n_16week = 7, 9, 6; n_21week = 12, 14, 10; n_28week = 12, 13, 10; n_31week = 12, 14, 10; n_36week = 12, 13, 10; n_40week = 11, 13, 10; n_44week = 10, 13, 10; n_50week =10, 13, 10; n_54week = 3, 4, 4) and male (black, bright green, dark green bars; n_7week = 10, 12, 10; n_11week = 8, 10, 8; n_16week = 11, 14, 11; n_21week = 11, 14, 11; n_28week = 8, 10, 8; n_31week = 8, 10, 8; n_36week = 7, 10, 7; n_40week = 8, 9, 8; n_44week = 8, 9, 8; n_50week = 7, 9, 7; n_54week = 3, 6, 3) mice. i, j Weights, as a percentage of the whole body, of inguinal adipose tissue, gonadal adipose tissue, liver, brown adipose tissue and skeletal muscle. Data were analysed using repeated measures mixed effects models. All data were analysed by a fitted mixed-effects model with correction for multiple comparisons using Dunnett’s method. k Representative immunoblot of Insr performed on mouse liver samples (n = 3). All animals/samples were handled in a strictly blinded manner. All data are presented as mean values ± SEM. Source data are provided as Source Data file.