Fig. 9. Tail blood glucose levels (mM) from glucose tolerance tests in inducible β-cell specific Insr knockout mice.

a Breeding and experimental design for inducible β-cell specific Insr knockout mice. b Glucose tolerance of Chow-fed Insr^wt/wt;MIP^Cre-ERTM;YFP^+/wt (black lines, solid circles, n = 7)) and Insr^f/f;MIP^Cre-ERTM;YFP^+/wt (yellow lines, solid triangles, n = 17) mice were examined at 4, 8, 16, and 20 weeks after tamoxifen injection at 8 weeks of age (3 × 200 mg/kg tamoxifen over a 1-week period). Data were analysed using repeated measures mixed-effects models. Data were analysed by a fitted mixed-effects model with correction for multiple comparisons using Dunnett’s method. All data are presented as mean values ± SEM. Source data are provided as Source Data file.