Table 1.
Sample characteristics of samples used in different phases of the study
| All | Screen positive group | Chart review set | PheCAP cases | Polysomnography sample | |
|---|---|---|---|---|---|
| N | 100 616 | 15 741 | 300 | 4876 | 4544 |
| Women, N (%) | 56 910 (56.56) | 6784 (43.10) | 137 (45.67) | 1887 (38.70) | 2512 (55.28) |
| Mean age (IQR) | 58.20 (25.65) | 57.18 (18.19) | 58.27 (18.94) | 57.59 (16.87) | 56.77 (24.60) |
| Mean BMI (IQR) | 27.25 (7.78) | 32.05 (9.66) | 31.16 (10.48) | 33.61 (10.15) | 30.54 (9.73) |
| Race/ethnicity | |||||
| Asian, N (%) | 2680 (2.66) | 254 (1.62) | 3 (1.00) | 73 (1.50) | 113 (2.49) |
| Black, N (%) | 4930 (4.90) | 941 (5.98) | 18 (6.00) | 356 (7.30) | 585 (12.87) |
| Hispanic/Latino, N (%) | 3778 (3.75) | 590 (3.75) | 15 (5.00) | 188 (3.86) | 386 (8.49) |
| White, N (%) | 85 495 (84.97) | 13 393 (85.08) | 255 (85.00) | 4084 (83.77) | 2993 (65.87) |
| Other race/ethnicity, N (%) | 3733 (3.71) | 563 (3.58) | 9 (3.00) | 174 (3.57) | 467 (10.28) |
| Language spoken | |||||
| English, N (%) | 97 134 (96.54) | 15 186 (96.47) | 285 (95.00) | 4711 (96.64) | 3971 (87.39) |
| Spanish, N (%) | 1456 (1.45) | 220 (1.40) | 4 (1.33) | 76 (1.56) | 442 (9.73) |
| Other languages, N (%) | 2026 (2.01) | 335 (2.13) | 11 (3.67) | 88 (1.80) | 131 (2.88) |
Note: “Screen positive” had one or more PheCode diagnoses for sleep apnea (327.3) or obstructive sleep apnea (327.32). The 300 participants in “Chart Review Set” were obtained from the Screen Positive Group and used to perform PheCAP phenotyping. “PheCAP Cases” were classified by lead PheCAP algorithm (PheCAP SICDNLP and NLP CUIs in Table 2). Age and BMI are presented as medians (interquartile range). All other fields, apart from sample size, are presented as total size (percentage). Age and BMI data were based on the first sleep apnea diagnosis date for PheCode cases, the last available visit date for PheCode controls, and the first available polysomnographic recording for the polysomnography sample.
Abbreviations: BMI: body mass index; IQR: interquartile range.