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. 2022 Feb 8;8:51. doi: 10.1038/s41420-022-00846-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The DEGs related to LC were analyzed using bioinformatic tools. ECM1 was selected from the DEGs and was then used to modify HF-MSCs. The cells were injected into mice with CCl₄-induced LC through the tail vein. Four weeks after cell transplantation, serum and liver tissue were collected for HE and Masson staining and Western blotting and immunofluorescence detection.