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. Author manuscript; available in PMC: 2022 Feb 9.
Published in final edited form as: Dev Psychobiol. 2020 Aug 17;63(1):114–124. doi: 10.1002/dev.22026

Figure 3.

Figure 3

OXTR DNA methylation blunts association between Neighborhood Harshness and reward sensitivity in Caudate. Maximum likelihood estimation of simple slopes for OXTR × Neighborhood Harshness interactions on neural activation in caudate for both CpG sites. (a) High methylation (orange line), defined as one standard deviation away from the Z-transformed methylation percentage, blunts the positive association between Neighborhood Harshness and reward activation relative to individuals with mean (black dashed line) or low levels of methylation (1 standard deviation below the mean, blue line). (b) The same association is found in CpG site −934.