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. Author manuscript; available in PMC: 2022 Feb 9.
Published in final edited form as: Dev Psychobiol. 2020 Aug 17;63(1):114–124. doi: 10.1002/dev.22026

Figure 4.

Figure 4

OXTR DNA Methylation reverses association between Neighborhood Harshness and reward sensitivity in OFC. Maximum likelihood estimation of simple slopes for OXTR × Neighborhood Harshness interactions on neural activation in OFC. Individuals with High Methylation at CpG site −924 (orange line) show increased anticipatory activation in OFC if they experienced low Neighborhood Harshness during adolescence. In contrast, those with low levels of methylation (blue line) show low activation in the OFC if they experienced low Neighborhood Harshness, but higher activation if they experienced high Neighborhood Harshness. This indicates an epigenetic by environment interaction on OFC response to the anticipation of rewards.