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. Author manuscript; available in PMC: 2022 May 7.
Published in final edited form as: Behav Brain Res. 2021 Feb 18;405:113187. doi: 10.1016/j.bbr.2021.113187

Figure 1. Identification of causal mutation.

Figure 1.

a. Fine mapping with a panel of SNP markers in 63 affected mice identified 7 key recombinants that narrowed the critical region to 498kb bounded by rs37841890 and rs30309434. b. Exome sequencing identified the deletion of a single guanine nucleotide in exon 2 of Cisd2 in B6.DDY-Cisd2m1Lmt mice. The single base deletion is predicted to result in a frameshift that introduces a string of aberrant amino acids and a premature stop codon. c. Cisd2 mRNA levels were lower in brain tissue from mutant (MUT) compared to wildtype (WT) mice but the difference was not significant.