Table 2.
Prevalence and distribution of TERT mutations in cancer genomes. The prevalence of TERT mutations in given as percentage and as total number of cases
Cancer type | Our study | Prevalence of mutations in published literatures | ||
---|---|---|---|---|
Prevalence of mutations | c.1-124C>T (C228T) | c.1-146 C>T (C250T) | ||
Urinary bladder | 31/47 (66.0%) | 24/31 (77.4%) | 7/31 (22.6%) | 29–100% [3, 6, 7, 35–38, 51] |
Pancreatobiliary | 19/127 (15.0%) | 16/19 (84.2%) | 3/19 (15.8%) | 0–7% [5, 9, 42, 52] |
Liver | 22/41 (53.7%) | 19/22 (86.4%) | 3/22 (13.6%) | 29–65% [35, 39, 40] |
Melanoma | 12/90 (13.2%) | 5/12 (41.7%) | 7/12 (58.3%) | 60–100% [4, 15, 34] |