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. 2022 Feb 9;10:18. doi: 10.1186/s40478-022-01321-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The percentage of S100B immunoreactive cells is lower in PitNETs compared to the APG. A Representative images of S100B immunoreactive cells found in the normal APG, and in gonadotroph, corticotroph, and Pit1 PitNETs. Lower panels show an enlarged view of the dashed insets. Scale bars = 20 µm (top), and 100 µm (bottom). B Percentage of S100B + cells in the tumour tissue of 54 PitNETs (median = 0.18%) versus 4 normal APG samples (median = 3.95%). Statistical test: Mann–Whitney, p = 0.003 (**). Graph—median with interquartile range. C Percentage of S100B + cells in matching tumour (median = 0.13%, range 0.00%-3.42%) versus adjacent APG tissue (median = 3.17%, range 1.71–11.68%) from 9 patients (P) with PitNETs. Statistical test: Wilcoxon matched paired test. Abbreviations: human pituitary neuroendocrine tumours (PitNETs), anterior pituitary gland (APG)