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. 2022 Feb 9;10:18. doi: 10.1186/s40478-022-01321-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — S100B + cells show an interpatient and an intratumoural heterogeneous distribution in gonadotroph tumours. A Quantification of S100B + cells on a gonadotroph tumour (Gon#3) showing a variation of more than 100-fold between different areas quantified. Top panel shows the four tumour areas (colour-coded in red, blue, orange, and green) that we defined and quantified on the scanned slide. The spatial plot represents each quantified cell as a red dot, and percentages for each quantified areas are noted. Lower panel shows enlarged views of S100B immunostaining in the indicated area (a, b, and c). Scale bars = 2 mm (top panel), 50 µm (lower panel). B Graph showing the percentage of S100B + cells quantified in multiple areas of 26 gonadotroph tumours (Gon#). Each dot plots the percentage of S100B + cells in a defined tumour area. Horizontal dashed line corresponds to a threshold of 1% S100B + cells. Vertical dashed line splits gonadotroph tumours with almost no expression of S100B among quantified areas and gonadotroph tumours presenting areas with variable percentages of detected S100B + cells. Abbreviation: immunohistochemistry (IHC)