Table 3. Cannabinoid receptor 1 (CNR1) rs12720071 polymorphism genotype and cognitive performance in patients with schizophrenia.

Cognitive domain/genetic model	n	Mean (SE)	Difference	95%CI	p-value
Working memory
Codominant
T/T	17	8.7 (1.1)	0
C/T	48	13.2 (0.6)	4.5	2.1 to 7
C/C	4	8 (3)	-0.7	-5.5 to 4.1	0.00062**
Dominant
T/T	17	8.7 (1.1)	0
C/T-C/C	52	12.8 (0.6)	4.1	1.6 to 6.6	0.00175**
Recessive
T/T-C/T	65	12.1 (0.6)	0
C/C	4	8 (3)	-4.1	-8.9 to 0.8	0.10495
Overdominant
T/T-C/C	21	8.6 (1)	0
C/T	48	13.2 (0.6)	4.7	2.4 to 6.9	0.00012**
log-additive
0, 1, 2			2	-0.1 to 4.2	0.0709
Motor speed
Codominant
T/T	17	51.6 (4.7)	0
C/T	48	48.8 (2.4)	-2.8	-12.5 to 6.8
C/C	4	21 (10.5)	-30.6	-49.7 to -11.6	0.00802*
Dominant
T/T	17	51.6 (4.7)	0
C/T-C/C	52	46.7 (2.5)	-4.9	-15.1 to 5.2	0.34217
Recessive
T/T-C/T	65	49.6 (2.1)	0
C/C	4	21 (10.5)	-28.6	-46.1 to -11	0.0021**
Overdominant
T/T-C/C	21	45.8 (5)	0
C/T	48	48.8 (2.4)	3	-6.5 to 12.6	0.5367
log-additive
0,1,2			-9.2	-17.4 to -1	0.03091*
Verbal fluency
Codominant
T/T	17	27.6 (2.4)	0
C/T	48	30.7 (1.5)	3	-2.6 to 8.7
C/C	4	12.2 (3.7)	-15.4	-26.6 to -4.2	0.00361**
Dominant
T/T	17	27.6 (2.4)	0
C/T-C/C	52	29.2 (1.6)	1.6	-4.4 to 7.7	0.60125
Recessive
T/T-C/T	65	29.9 (1.3)	0
C/C	4	12.2 (3.7)	-17.6	-28 to -7.3	0.00138**
Overdominant
T/T-C/C	21	24.7 (2.4)	0
C/T	48	30.7 (1.5)	6	0.5 to 11.5	0.03693*
log-additive			-2.5	-7.5 to 2.5	0.33845
0,1,2
Global cognitive performance
Codominant
T/T	17	-1.6 (0.2)	0
C/T	48	-1.3 (0.1)	0.3	-0.2 to 0.7
C/C	4	-2.8 (0.4)	-1.2	-2.1 to -0.3	0.00244**
Dominant
T/T	17	-1.6 (0.2)	0
C/T-C/C	52	-1.4 (0.1)	0.2	-0.3 to 0.6	0.5081
Recessive
T/T-C/T	65	-1.3 (0.1)	0
C/C	4	-2.8 (0.4)	-1.4	-2.3 to -0.6	0.0011**
Overdominant
T/T-C/C	21	-1.8 (0.2)	0
C/T	48	-1.3 (0.1)	0.5	0.1 to 1	0.02419*
log-additive
0, 1, 2			-0.2	-0.6 to 0.2	0.38594

SE = standard error.

* p < 0.05; ** p < 0.005 (corrected for multiple comparisons).