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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Ageing Res Rev. 2021 Dec 3;73:101535. doi: 10.1016/j.arr.2021.101535

Figure 2.

Figure 2.

Functional genomics of preeclampsia illustrating challenges in interpreting GWAS. (A) In silico analysis to identify candidate causal variants and genes of preeclampsia informed by GWAS. (B) High-throughput screens such as a massive parallel reporter assay (MPRA) to investigate a large number of regulatory variants within a single experiment for identification and prioritization of functional variants. (C) Cell modeling using CRISPR-engineered pluripotent stem cell followed by differentiation into multiple cell types to study cell type-specific functional impact of variants in vitro. (D) Mouse modeling to study the functional impact of variants in vivo.