Table 2:

GWAS Approach of Preeclampsia (PE)

Study participants	SNPs	P-values	OR	Nature of variant(s)	Mapped gene(s)	Reference
538 PE cases and 540 controls; Caucasian women from Australia	rs7579169 rs12711941	3.58e-7 4.26e-7	1.57 1.56	intergenic intergenic	INHBB INHBB	(Johnson et al., 2012)
177 PE cases and 116 controls; Caucasian women from Iowa	rs1426409 rs17686866 rs9831647 rs10743565	2.58e-2 (allelic); 3.14e-6(genotypic) 1.97e-5(allelic); 3.80e-6(genotypic) 1.65e-2(allelic); 9.36e-6(genotypic) 5.00e-6(allelic); 1.64e-5(genotypic)	not reported	intergenic intronic intronic intronic	KIAA1239 ESRRG LMCD1 IFLTD1	(Zhao et al., 2012)
21 PE cases and 1,049 controls; Afro-Caribbean women from Barbados 50 PE cases and 1,207 controls; women of European ancestry 62 PE cases and 661 controls; Hispanic women	rs11617740 rs7322722 rs17412740	7.3e-7 (Afro-Carribean) 1.23e-6 (European) 2.14e-6 (Hispanic)	16.69 2.93 6.08	intronic intronic intergenic	FGF14 MYCBP2 LZTS1	(Zhao et al., 2013)
GWAS + replication n = 4,380 cases and 310,238 controls; offspring from European women	(infant) rs4769613 rs12050029 rs149427560	5.40e-11 3.00e-6 4.10e-5	1.22 1.20 1.30	enhancer enhancer intergenic	Flt-1 Flt-1 Flt-1	(McGinnis et al., 2017)
meta -analysis of eight previously unreported GWAS consisting of 9,515 PE cases and 157,719 controls; women from Europe and Central Asia. Follow-up with additional samples of European and Kazakh origin (2,635 PE cases; 6,379 controls) (maternal) meta-analysis consisting of 6,775 offspring born of PE complicated pregnancies and 375,372 controls; women from Europe and Central Asia. (infant)	(maternal) rs1421085 rs259983 rs1918975 rs1458038 rs10774624 (infant) rs4769612	1.2e-9 2.9e-10 1.2e-8 1.2e-8 1.7e-8 4.3e-14	1.11 1.17 1.10 1.11 1.11 1.19	intronic intronic intronic intergenic intronic intergenic	FTO ZNF831 MECOM PRDM8, FGF5 LINC02356 Flt-1	(Steinthorsdottir et al., 2020