Table 2.
Subdomain Mean Scores Regressed on MDD GPS and Schizophrenia GPS
| N | MDD GPS | Schizophrenia GPS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| f | b (SE) | z (P) | β | f | b (SE) | z (P) | β | ||
| Age 16 | |||||||||
| Flat affect | 6005 | 0.3 | 0.019 (0.005) | 3.504 (<.001) | 0.05 | 1 | 0.014 (0.005) | 2.659 (.008) | 0.037 |
| Alogia | 6006 | 1 | 0.010 (0.008) | 1.289 (.197) | 0.017 | 0.3 | 0.007 (0.008) | 0.893 (.372) | 0.012 |
| Avolition | 5995 | 0.3 | 0.030 (0.007) | 3.986 (<.001) | 0.054 | 0.01 | –0.004 (0.008) | –0.496 (.620) | –0.007 |
| Anhedonia | 5971 | 1 | 0.029 (0.009) | 3.359 (.001) | 0.046 | 0.3 | 0.008 (0.009) | 0.922 (.356) | 0.012 |
| Asociality | 5971 | 1 | 0.028 (0.006) | 4.321 (<.001) | 0.056 | 0.01 | –0.007 (0.008) | –0.858 (.391) | –0.013 |
| Age 17 | |||||||||
| Flat affect | 1818 | 0.3 | 0.016 (0.012) | 1.410 (.159) | 0.035 | 1 | 0.027 (0.012) | 2.162 (.031) | 0.057 |
| Alogia | 1815 | 1 | 0.019 (0.015) | 1.253 (.210) | 0.03 | 1 | 0.006 (0.016) | 0.387 (.699) | 0.01 |
| Avolition | 1816 | 1 | 0.054 (0.016) | 3.367 (.001) | 0.084 | 1 | 0.038 (0.016) | 2.404 (.016) | 0.058 |
| Anhedonia | 1807 | 1 | 0.046 (0.019) | 2.433 (.015) | 0.065 | 0.3 | 0.017 (0.017) | 0.967 (.334) | 0.023 |
| Asociality | 1794 | 1 | 0.025 (0.016) | 1.539 (.124) | 0.04 | 0.01 | –0.019 (0.016) | –1.153 (.249) | –0.03 |
| Age 22 | |||||||||
| Flat affect | 6274 | 0.3 | 0.018 (0.006) | 3.195 (.001) | 0.041 | 0.01 | –0.004 (0.006) | –0.737 (.461) | –0.009 |
| Alogia | 6278 | 1 | 0.009 (0.008) | 1.072 (.284) | 0.014 | 0.01 | 0.002 (0.008) | 0.225 (.822) | 0.003 |
| Avolition | 6276 | 1 | 0.028 (0.008) | 3.487 (<.001) | 0.045 | 0.01 | –0.006 (0.008) | –0.738 (.460) | –0.01 |
| Anhedonia | 6251 | 1 | 0.030 (0.009) | 3.233 (.001) | 0.043 | 0.3 | –0.007 (0.009) | –0.729 (.466) | –0.01 |
| Asociality | 6259 | 0.3 | 0.029 (0.008) | 3.702 (<.001) | 0.049 | 1 | 0.007 (0.008) | 0.893 (.372) | 0.011 |
Note: Subdomain mean scores regressed on MDD and schizophrenia GPS separately. Related and unrelated individuals included, using cluster-robust SE. Results shown for the most predictive GPS f. GPS, genome-wide polygenic score; MDD, major depressive disorder; f, fraction of causal markers; b, unstandardized regression coefficient; β, standardized regression coefficient. Bold typeset represents significance under corrected q < .05 threshold.