Fig. 4.

RA-induced reduction of proliferation is less dramatic in sHIF + RA cells. SH-SY5Y cells were co-stained for the proliferative markers BrdU and Ki67. The amount of BrdU + cells in the undiff. A The group was higher than both sSCR + RA (B) and sHIF + RA (C) cells. However, inhibition of HIF-1α in sHIF + RA cells leads to a partial recovery of the proliferative status with an increased amount of BrdU positive cells than sSCR + RA (D). Amount of Ki67 + cells in the groups Undiff. (E), sSCR + RA (F) and sHIF + RA (G) followed the same pattern (H) as for BrdU +